- a hypochondriac pigeon named Lewis who suffers from vertigo.
- A white house-cat named Tedd who thinks he's a black stray.
- Mel an independent minded female rabbit who can't live without males.
- And Randal, a rough and tough pitbull who, after being "fixed" is riddled with sexual identity issues.
All their individual problems leads them to a city veterinary hospital where the group learns to work together. The series follows this odd band of animals as they episodically sneak out of the veterinary hospital and get into trouble in a large urban setting.